日韩成人在线网站_国产精品观看_丝袜美腿中文字幕_涩涩app_欧美猛男大巨大1069_777在线视频_西西人体大胆4444www_九月色婷婷_天堂中文在线看_日本精品一级_午夜影院久久_男生操女生的_日本 奴役 捆绑 受虐狂_91免费在线播放_成人黄色免费观看

Here, Professor Shaobing Zhou and Professor Guo Xing of Southwest Jiaotong University developed a LyP1 polypeptide-modified bacterial outer membrane vesicle (LOMV) containing PD-1 plasmid, which realized the self-blocking of PD-L1 in tumor cells. Express the targeting polypeptide LyP1 in E. coli, extract LOMVs, and encapsulate the PD-1 plasmid to obtain LyP1-OMVs@PD-1 nanocarrier. After intravenous injection, these nanocarriers accumulate in tumor tissues through the targeting ability of OMV, and are internalized in tumor cells through LyP1, and then the PD-1 plasmid is sent to the nucleus, causing tumor cells to express PD-1. Self-expressed PD-1 binds to PD-L1 expressed by itself and neighboring tumor cells to achieve self-blocking, and CTL is reactivated to destroy tumor cells. At the same time, the outer membrane protein of LOMV can recruit cytotoxic lymphocytes and natural killer cells to tumor tissues, stimulate them to secrete IFN-γ, and improve the anti-tumor activity of PD-1/PD-L1 self-blocking therapy. In addition, OMVs differentiated CTL into central memory T cells, which produced long-term immunity. Experimental results show that, compared with non-targeted OMV, LyP1 has an effective ability to target tumors and accumulate in tumors. Bacterial outer membrane vesicles also attract CTL and NK cells to tumor tissues to achieve dual anti-tumor effects. This strategy has significantly improved the therapeutic effect of tumors and provides new ideas for the development of tumor immunotherapy nanomedicine.

Original link: https://onlinelibrary.wiley.com/doi/abs/10.1002/adma.202106307