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Prussian blue regulates microenvironment prevention and treatment of diseases is a new strategy using Prussian blue (Prussian blue) as a nanoenzyme, by regulating the redox balance in the inflammatory microenvironment, so as to inhibit inflammatory response and oxidative stress, and prevention and treatment of a variety of diseases. Prussian blue is a dark blue coordination compound that is highly biocompatible, stable, catalytic and optical, and can be used in drug delivery, photothermal therapy, and photodynamic therapy. Prussian blue regulation of microenvironment for prevention and treatment of diseases can improve the targeting and bioavailability of drugs, reduce toxic and side effects, and enhance the therapeutic effect.

A Prussian blue-based nanocatalyst that produces antioxidants in the microenvironment of ischemic stroke, thereby reducing oxidative stress and inflammation and protecting nerve cells. The nanocatalyst showed excellent biosafety, stability and targeting, and demonstrated its remarkable neuroprotective effects in vitro and in vivo.

A Prussian blue-based nanocatalyst that can produce antioxidants in the microenvironment of diabetic trauma, thereby reducing oxidative stress and inflammatory responses and promoting trauma healing. The nanocatalyst demonstrated highly efficient catalytic activity, biodegradability and biocompatibility, and demonstrated its excellent trauma repair efficacy in vitro and in vivo.

A Prussian blue-based nanocatalyst that can produce antioxidants in the tumor microenvironment, thereby reducing the resistance and tolerance of tumor cells and enhancing the efficacy of photothermal therapy. The nanocatalyst showed excellent optical properties, biosafety and targeting, and demonstrated its remarkable antitumor effect in vitro and in vivo.

Reference Documentation:

[1]A Prussian blue nanocatalyst for modulating tumor microenvironment and enhancing photothermal therapy of cancer.